Tang, Jia-Lin Zhou, Zong-Yuan Yang, Tao Yao, Can Wu, Lin-Wei Li, Guo-You Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus <i>Penicillium sclerotiorum</i> cib-411 Nine new azaphilone alkaloids, penazaphilones A–I (<b>1</b>–<b>9</b>), were isolated from the solid fermented rice culture of <i>Penicillium sclerotiorum</i> cib-411. The structures of compounds <b>1</b>–<b>9</b> were elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures of <b>5</b> and <b>8</b> were confirmed by X-ray crystallographic analyses. Biological evaluation showed that compounds <b>1</b>, <b>5</b>, <b>6</b>, and <b>8</b> inhibited the production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide with IC<sub>50</sub> values of 15.29, 9.34, 9.50, and 7.05 μM, respectively. Meanwhile, they did not exhibit obvious cytotoxicity at a concentration of 50.0 μM. exhibit;Fungus Penicillium sclerotiorum cib -411;nitric oxide;concentration;Penicillium sclerotiorum cib -411.;azaphilone alkaloids;7.05 μ M;rice culture;IC 50 values;Anti-inflammatory Activity;X-ray;50.0 μ M;compounds 1;penazaphilone;Biological evaluation;analyses;RAW 264.7 cells;Azaphilone Alkaloids;cytotoxicity;lipopolysaccharide;NMR;HRESIMS;CD spectroscopic data 2019-01-31
    https://acs.figshare.com/articles/dataset/Azaphilone_Alkaloids_with_Anti-inflammatory_Activity_from_Fungus_i_Penicillium_sclerotiorum_i_cib-411/7722143
10.1021/acs.jafc.8b05628.s002