10.1021/acs.joc.8b02755.s001 Wen-Ming Shu Wen-Ming Shu Jian-Xin He Jian-Xin He Xun-Fang Zhang Xun-Fang Zhang Shuai Wang Shuai Wang An-Xin Wu An-Xin Wu TFA-Mediated DMSO-Participant Sequential Oxidation/1,3-Dipolar Cycloaddition Cascade of Pyridinium Ylides for the Assembly of Indolizines American Chemical Society 2019 K 2 S 2 O 8 Sequential cycloaddition DMSO acts Assembly transition-metal-free reaction Oxidation presence Pyridinium Ylides pyridinium salts trifluoroacetic acid method synthesis dimethyl sulfoxide oxidation DMSO-Participant Cascade indolizine derivatives TMEDA trimethylethylenediamine TFA Indolizine cascade TFA-Mediated Cycloaddition one-carbon source 2019-02-12 15:12:43 Journal contribution https://acs.figshare.com/articles/journal_contribution/TFA-Mediated_DMSO-Participant_Sequential_Oxidation_1_3-Dipolar_Cycloaddition_Cascade_of_Pyridinium_Ylides_for_the_Assembly_of_Indolizines/7707650 A trifluoroacetic acid (TFA)-mediated cascade oxidation/1,3-dipolar cycloaddition reaction of stabilized pyridinium salts with dimethyl sulfoxide (DMSO) has been developed in the presence of K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> and trimethylethylenediamine (TMEDA). In this transition-metal-free reaction, DMSO acts as a one-carbon source, thus providing a convenient method for the efficient and direct synthesis of various indolizine derivatives.