Zhang, Jingyi Guo, Meichao Chen, Yajuan Zhang, Shuangshuang Wang, Xiao-Na Chang, Junbiao Synthesis of Amino-Substituted α- and δ‑Carbolines via Metal-Free [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles with Ynamides A metal-free [2 + 2 + 2] cycloaddition of alkyne-cyanamides or ynamide-nitriles with ynamides is described for the efficient synthesis of amino-substituted α- and δ-carbolines. This novel methodology is environmentally friendly and allows for highly regioselective access to carboline derivatives in good to excellent yields with wide functional group tolerance. Ynamide;cycloaddition;Amino-Substituted α-;ynamide;carboline derivatives;Functionalized Alkyne-Nitriles;alkyne-cyanamide;Synthesi;regioselective access;metal-free;group tolerance;δ- carbolines;ynamide-nitrile;Metal-Free;yield;Carboline;amino-substituted α-;novel methodology;synthesis;Cycloaddition 2019-02-08
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Amino-Substituted_-_and_Carbolines_via_Metal-Free_2_2_2_Cycloaddition_of_Functionalized_Alkyne-Nitriles_with_Ynamides/7697978
10.1021/acs.orglett.9b00021.s002