1,4-Palladium Shift/C(sp<sup>3</sup>)–H Activation Strategy for the Remote Construction of Five-Membered Rings Ronan Rocaboy Olivier Baudoin 10.1021/acs.orglett.9b00187.s001 https://acs.figshare.com/articles/journal_contribution/1_4-Palladium_Shift_C_sp_sup_3_sup_H_Activation_Strategy_for_the_Remote_Construction_of_Five-Membered_Rings/7697873 1,<i>n</i>-Metal shift is an elegant alternative approach enabling the functionalization of remote C–H bonds from simple precursors. In this work, we report a novel and simple Pd<sup>0</sup>-catalyzed domino reaction involving 1,4-palladium shift and C­(sp<sup>3</sup>)–H activation and leading to (fused) five-membered rings. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (−)-pyrrolam. 2019-02-08 19:50:26 pyrrolam Five-Membered Strategy domino reaction access functionalization Palladium method Activation Remote Construction Shift activation Metal shift palladium indanone Pd 0 arylidene γ- lactams precursor alternative approach synthesis five-membered rings bond