1,4-Palladium Shift/C(sp<sup>3</sup>)–H Activation
Strategy for the Remote Construction of Five-Membered Rings
Ronan Rocaboy
Olivier Baudoin
10.1021/acs.orglett.9b00187.s001
https://acs.figshare.com/articles/journal_contribution/1_4-Palladium_Shift_C_sp_sup_3_sup_H_Activation_Strategy_for_the_Remote_Construction_of_Five-Membered_Rings/7697873
1,<i>n</i>-Metal shift is an elegant alternative approach
enabling the functionalization of remote C–H bonds from simple
precursors. In this work, we report a novel and simple Pd<sup>0</sup>-catalyzed domino reaction involving 1,4-palladium shift and C(sp<sup>3</sup>)–H activation and leading to (fused) five-membered
rings. This method allowed access to a broad range of valuable arylidene
γ-lactams and indanones and was applied to the formal synthesis
of (−)-pyrrolam.
2019-02-08 19:50:26
pyrrolam
Five-Membered
Strategy
domino reaction
access
functionalization
Palladium
method
Activation
Remote Construction
Shift
activation
Metal shift
palladium
indanone
Pd 0
arylidene γ- lactams
precursor
alternative approach
synthesis
five-membered rings
bond