Landry, Matthew L. McKenna, Grace M. Burns, Noah Z. Enantioselective Synthesis of Azamerone A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of natural-product-relevant chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade. motif;dichlorinated meroterpenoid azamerone;boronic hemiester;enantioenriched forms;cycloaddition;quinone diazide;novel enantioselective chloroetherification reaction;tetrazine;natural-product-relevant chiral organochlorides;strategy;tactic;accessing;paucity;route features;Azamerone;late-stage;cascade;Enantioselective Synthesis;synthesis;Pd-catalyzed cross-coupling 2019-02-01
    https://acs.figshare.com/articles/dataset/Enantioselective_Synthesis_of_Azamerone/7692155
10.1021/jacs.8b12566.s001