Enantioselective Synthesis of Azamerone Matthew L. Landry Grace M. McKenna Noah Z. Burns 10.1021/jacs.8b12566.s001 https://acs.figshare.com/articles/dataset/Enantioselective_Synthesis_of_Azamerone/7692155 A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of natural-product-relevant chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade. 2019-02-01 00:00:00 motif dichlorinated meroterpenoid azamerone boronic hemiester enantioenriched forms cycloaddition quinone diazide novel enantioselective chloroetherification reaction tetrazine natural-product-relevant chiral organochlorides strategy tactic accessing paucity route features Azamerone late-stage cascade Enantioselective Synthesis synthesis Pd-catalyzed cross-coupling