Chloraserrtone A, a Sesquiterpenoid Dimer from <i>Chloranthus
serratus</i>
Bai Bai
Shao-Xia Ye
De-Po Yang
Long-Ping Zhu
Gui-Hua Tang
Yun-Yun Chen
George Qian Li
Zhi-Min Zhao
10.1021/acs.jnatprod.8b00418.s002
https://acs.figshare.com/articles/dataset/Chloraserrtone_A_a_Sesquiterpenoid_Dimer_from_i_Chloranthus_serratus_i_/7680362
Chloraserrtone A (<b>1</b>),
a new sesquiterpenoid dimer
with two lindenane-type sesquiterpenoid monomers bridged by two six-membered
rings, was obtained from <i>Chloranthus serratus</i>. A
combination of UV, IR, NMR, HRESIMS, and X-ray diffraction data were
used to elucidate the structure of <b>1</b>. Compound <b>1</b> represents the first lindenane-type sesquiterpenoid dimer
with extremely unique C-15–C-15′, C-4–C-6′,
and C-6–C-11′ linkages to form two six-membered rings
between the monomeric units. A plausible biosynthesis toward chloraserrtone
A is proposed. This new compound (<b>1</b>), together with the
known lindenane dimers (<b>2</b>–<b>11</b>), were
assessed for their inhibitory effects on lipopolysaccharide-induced
NO production in RAW264.7 cells. Compound <b>6</b> showed activity
with an IC<sub>50</sub> value of 3.7 μM.
2019-02-06 14:47:53
Chloranthus serratus Chloraserrtone
lindenane-type sesquiterpenoid dimer
six-membered rings
X-ray diffraction data
RAW 264.7 cells
Compound
IR
lindenane-type sesquiterpenoid monomers bridged
3.7 μ M
NMR
IC 50 value
UV
HRESIMS