Chloraserrtone A, a Sesquiterpenoid Dimer from <i>Chloranthus serratus</i> Bai Bai Shao-Xia Ye De-Po Yang Long-Ping Zhu Gui-Hua Tang Yun-Yun Chen George Qian Li Zhi-Min Zhao 10.1021/acs.jnatprod.8b00418.s002 https://acs.figshare.com/articles/dataset/Chloraserrtone_A_a_Sesquiterpenoid_Dimer_from_i_Chloranthus_serratus_i_/7680362 Chloraserrtone A (<b>1</b>), a new sesquiterpenoid dimer with two lindenane-type sesquiterpenoid monomers bridged by two six-membered rings, was obtained from <i>Chloranthus serratus</i>. A combination of UV, IR, NMR, HRESIMS, and X-ray diffraction data were used to elucidate the structure of <b>1</b>. Compound <b>1</b> represents the first lindenane-type sesquiterpenoid dimer with extremely unique C-15–C-15′, C-4–C-6′, and C-6–C-11′ linkages to form two six-membered rings between the monomeric units. A plausible biosynthesis toward chloraserrtone A is proposed. This new compound (<b>1</b>), together with the known lindenane dimers (<b>2</b>–<b>11</b>), were assessed for their inhibitory effects on lipopolysaccharide-induced NO production in RAW264.7 cells. Compound <b>6</b> showed activity with an IC<sub>50</sub> value of 3.7 μM. 2019-02-06 14:47:53 Chloranthus serratus Chloraserrtone lindenane-type sesquiterpenoid dimer six-membered rings X-ray diffraction data RAW 264.7 cells Compound IR lindenane-type sesquiterpenoid monomers bridged 3.7 μ M NMR IC 50 value UV HRESIMS