10.1021/acs.joc.8b02977.s001 Yuanyong Yang Yuanyong Yang Yingxian Li Yingxian Li Cheng Cheng Cheng Cheng Guo Yang Guo Yang Shuiying Wan Shuiying Wan Jiquan Zhang Jiquan Zhang Yuanhu Mao Yuanhu Mao Yonglong Zhao Yonglong Zhao Lin Zhang Lin Zhang Chun Li Chun Li Lei Tang Lei Tang Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2<i>H</i>,4<i>H</i>)‑dione Derivatives American Chemical Society 2019 dione Base-catalyzed Derivative hydroxylation methodology Isoquinoline hydroxylated tetrahydroisoquinoline core structure heteroaryl Reductant-Free Aerobic Hydroxylation transition-metal-free substrate reductant-free conditions alkyl groups aryl reductive process 2019-01-15 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Reductant-Free_Aerobic_Hydroxylation_of_Isoquinoline-1_3_2_i_H_i_4_i_H_i_dione_Derivatives/7646996 Base-catalyzed efficient hydroxylation of isoquinoline-1,3­(2<i>H</i>,4<i>H</i>)-diones with air under transition-metal-free and reductant-free conditions was established. This methodology is essentially mild and compatible with a broad range of substrates, including aryl, heteroaryl, and alkyl groups. Also, the product could be simply transformed into a hydroxylated tetrahydroisoquinoline core structure through a reductive process.