Promotion of Mefenamic Acid Nucleation by a Surfactant
Additive, Docusate Sodium
Katalin Bodnár
Sarah P. Hudson
Åke C. Rasmuson
10.1021/acs.cgd.8b00995.s001
https://acs.figshare.com/articles/journal_contribution/Promotion_of_Mefenamic_Acid_Nucleation_by_a_Surfactant_Additive_Docusate_Sodium/7579889
The
influence of docusate sodium (DOSS) on the nucleation of mefenamic
acid (MEF) has been studied in different dimethylacetamide (DMA)–water
mixtures. A series of induction time experiments were conducted under
moderate supersaturations, varying the solvent composition and the
concentration of DOSS. In 40% DMA–60% water, the presence of
0.1 and 0.2 mg/mL DOSS increased the nucleation rate. Evaluating the
results by the classical nucleation theory reveals that the pre-exponential
factor (<i>A</i>) increases by approximately 50% while the
interfacial energy is essentially uninfluenced. It is also found that
the crystal growth rate becomes higher in the presence of DOSS. It
is thus hypothesized that transport and desolvation of MEF molecules
are facilitated in the presence of DOSS. With increasing amount of
DMA in the binary solvent mixture, the influence of DOSS appears to
decrease.
2018-12-18 00:00:00
DMA
nucleation theory
DOSS
docusate sodium
mefenamic acid
Docusate Sodium
presence
nucleation rate
MEF molecules
induction time experiments
Surfactant Additive
pre-exponential factor
crystal growth rate