%0 Journal Article %A Melot, Romain %A Craveiro, Marcus V. %A Bürgi, Thomas %A Baudoin, Olivier %D 2019 %T Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd0‑Catalyzed Asymmetric C(sp3)–H Activation %U https://acs.figshare.com/articles/journal_contribution/Divergent_Enantioselective_Synthesis_of_Nor_illudalane_Sesquiterpenes_via_Pd_sup_0_sup_Catalyzed_Asymmetric_C_sp_sup_3_sup_H_Activation/7579838 %R 10.1021/acs.orglett.8b04086.s001 %2 https://acs.figshare.com/ndownloader/files/14077742 %K chiral substrate %K quaternary stereocenter %K Divergent Enantioselective Synthesis %K target molecules %K Asymmetric %K enantioenriched form %K enantioselective synthesis %K arylation %K combination %K Sesquiterpene %K stereoselectivity %K Catalyzed %K Pd 0 %K deliquinone %K approach %K sesquiterpene %K russujaponol %K Activation %K catalyst %X A divergent enantioselective synthesis of (nor)­illudalane sesquiterpenes was designed by using a Pd0-catalyzed asymmetric C­(sp3)–H arylation as a key step to control the isolated, highly symmetric quaternary stereocenter of the target molecules. A matched combination of chiral substrate and catalyst proved optimal to reach good levels of stereoselectivity. This approach enabled the synthesis of three (nor)­illudalanes, including (S)-deliquinone and (S)-russujaponol F, which are synthesized for the first time in enantioenriched form. %I ACS Publications