%0 Journal Article
%A Weems, Andrew C.
%A Easley, Alexandra
%A Roach, Sydney Reese
%A Maitland, Duncan J.
%D 2018
%T Highly
Cross-Linked Shape Memory Polymers with Tunable
Oxidative and Hydrolytic Degradation Rates and Selected Products Based
on Succinic Acid
%U https://acs.figshare.com/articles/journal_contribution/Highly_Cross-Linked_Shape_Memory_Polymers_with_Tunable_Oxidative_and_Hydrolytic_Degradation_Rates_and_Selected_Products_Based_on_Succinic_Acid/7533428
%R 10.1021/acsabm.8b00650.s001
%2 https://acs.figshare.com/ndownloader/files/14005709
%K bulk morphology
%K oxidative degradation
%K 30 days
%K Previous work
%K shape memory polymers
%K rate changes
%K 80 days
%K strain fixity
%K T g
%K ester SMPs
%K glass transition temperature
%K 140 days
%K ester networks
%K Tunable Oxidative
%K Cross-Linked Shape Memory Polymers
%K Selected Products
%K material system
%K ester network
%K hydrolytic degradation
%K alcohol triethanolamine
%K control materials
%K Hydrolytic Degradation Rates
%X Minimally
invasive medical devices are of great interest, with
shape memory polymers (SMPs) representing one such possibility for
producing these devices. Previous work with low density, highly porous
SMPs has demonstrated oxidative degradation, while attempts to incorporate
hydrolytic degradation have resulted in rapidly decreasing glass transition
temperature (Tg), ultimately preventing
strain fixity of the materials at clinically relevant temperatures.
Through esterification of the amino alcohol triethanolamine, an alcohol
containing network was synthesized and incorporated into SMPs. These
ester networks were used to control the bulk morphology of the SMP,
with the Tg remaining above 37 °C when
50% of the alcohol was contributed by the ester network. This methodology
also yielded SMPs that could degrade through both hydrolysis and oxidation;
by oxidation, the SMPs degrade at a similar rate as the control materials
(0.2%/day mass) for the first 30 days, at which point the rate changes
to 3.5%/day until the samples become too fragile to examine at 80
days. By comparison, control materials have lost approximately 30%
of mass by 140 days, at a constant rate of degradation, demonstrating
that the ester SMPs are a promising material system for producing
more rapidly degradable, soft, porous biomaterials.
%I ACS Publications