%0 Journal Article %A He, Chi %A P. Stratton, Thomas %A Baran, Phil S. %D 2018 %T Concise Total Synthesis of Herqulines B and C %U https://acs.figshare.com/articles/journal_contribution/Concise_Total_Synthesis_of_Herqulines_B_and_C/7505435 %R 10.1021/jacs.8b13029.s001 %2 https://acs.figshare.com/ndownloader/files/13903376 %K researcher %K insight %K Herqulines B %K alkaloids %K herqulines B %K reductive biosynthesis %K diketopiperizine %K tyrosine %K dimerization %K macrocyclization %K Concise %K Synthesi %X A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecutive reductions. Emerging from these studies are strategic insights on the synthesis of these strained alkaloids, as well as mild conditions for the exhaustive reduction of diketopiperizines. %I ACS Publications