10.1021/jacs.8b13029.s001
Chi He
Chi
He
Thomas P. Stratton
Thomas
P. Stratton
Phil S. Baran
Phil S.
Baran
Concise
Total Synthesis of Herqulines B and C
American Chemical Society
2018
researcher
insight
Herqulines B
alkaloids
herqulines B
reductive biosynthesis
diketopiperizine
tyrosine
dimerization
macrocyclization
Concise
Synthesi
2018-12-21 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Concise_Total_Synthesis_of_Herqulines_B_and_C/7505435
A simple
total synthesis of herqulines B and C is reported, modeled
on the reductive biosynthesis reported previously by other researchers.
Commencing from tyrosine, these alkaloids were fashioned through a
dimerization, macrocyclization, and four consecutive reductions. Emerging
from these studies are strategic insights on the synthesis of these
strained alkaloids, as well as mild conditions for the exhaustive
reduction of diketopiperizines.