10.1021/jacs.8b13029.s001 Chi He Chi He Thomas P. Stratton Thomas P. Stratton Phil S. Baran Phil S. Baran Concise Total Synthesis of Herqulines B and C American Chemical Society 2018 researcher insight Herqulines B alkaloids herqulines B reductive biosynthesis diketopiperizine tyrosine dimerization macrocyclization Concise Synthesi 2018-12-21 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Concise_Total_Synthesis_of_Herqulines_B_and_C/7505435 A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecutive reductions. Emerging from these studies are strategic insights on the synthesis of these strained alkaloids, as well as mild conditions for the exhaustive reduction of diketopiperizines.