Wang, Cong Li, Nan Zhu, Wen-Jing Gong, Jun-Fang Song, Mao-Ping Asymmetric Michael Addition of 2‑Acetyl Azaarenes to β‑CF<sub>3</sub>‑β-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex The first enantioselective Michael addition of 2-acetyl azaarenes to β-CF<sub>3</sub>-β-(3-indolyl)­nitroalkenes has been successfully achieved in the presence of a Co­(II)/(imidazoline-oxazoline) complex as the catalyst. The reaction affords a series of CF<sub>3</sub>- and 3-indole-containing adducts featuring a trifluoromethylated all-carbon quaternary stereocenter in good to excellent yields (up to 99%) and enantioselectivities (up to 96% <i>ee</i>). Furthermore, the functional groups in the adducts including CO, NO<sub>2</sub>, and the azaarene provide a large variety of useful transformations, leading to the formation of valuable intermediates such as optically active secondary alcohol, pyrroline, ester, and pyrrolidinone which all contain a 3-substituted indole and a trifluoromethylated all-carbon quaternary stereocenter. indolyl;Asymmetric Michael Addition;2- acetyl azaarenes;CF 3;enantioselective Michael addition;3- indole-containing adducts;trifluoromethylated all-carbon quaternary stereocenter 2018-12-13
    https://acs.figshare.com/articles/journal_contribution/Asymmetric_Michael_Addition_of_2_Acetyl_Azaarenes_to_CF_sub_3_sub_-_3-indolyl_nitroalkenes_Catalyzed_by_a_Cobalt_II_imidazoline-oxazoline_Complex/7505402
10.1021/acs.joc.8b02601.s001