Application of Polysaccharide-Based Chiral HPLC Columns
for Separation of Nonenantiomeric Isomeric Mixtures of Organometallic
Compounds
Masamichi Ogasawara
Yuuki Enomoto
Mizuho Uryu
Xicheng Yang
Ayami Kataoka
Atsushi Ohnishi
10.1021/acs.organomet.8b00819.s001
https://acs.figshare.com/articles/journal_contribution/Application_of_Polysaccharide-Based_Chiral_HPLC_Columns_for_Separation_of_Nonenantiomeric_Isomeric_Mixtures_of_Organometallic_Compounds/7491257
A series
of polysaccharide-based chiral stationary phase (CSP) columns, Daicel
Chiralpak IA, IB, and IC, were applied in the separation of the nonenantiomeric
isomers of various organometallic compounds and were found to be highly
effective in recognizing isomers of minor structural differences.
The CSP columns have succeeded to separate the double-bond regioisomers
in bridged (η<sup>5</sup>-formylcyclopentadienyl)manganese(I)
dicarbonyl complexes <b>1a</b>/<b>1b</b>, the structural
isomers of methylbutenylferrocene derivatives in <b>2a</b>/<b>2b</b> and <b>3a</b>/<b>3b</b>, and the geometrical
isomers of the (2-methyl-2-butenyl)ferrocenes in (<i>Z</i>)/(<i>E</i>)-<b>3b</b>. Due to the close similarity
of the isomeric compounds in these mixtures, separations of the components
are extremely difficult and could not be attained by conventional
methods such as silica gel column chromatography, silica gel HPLC,
recrystallization, distillation/sublimation, etc. Clearly, the polysaccharide-based
CSP columns have unique advantages in separation/purification technology,
and this study has shown potential usefulness of the CSP columns in
separation of not only enantiomeric but also nonenantiomeric mixtures.
2018-12-20 12:18:29
compound
polysaccharide-based CSP columns
Nonenantiomeric Isomeric Mixtures
separation
Polysaccharide-Based Chiral HPLC Columns
Daicel Chiralpak IA
silica gel column chromatography
silica gel HPLC
nonenantiomeric
CSP columns
mixture
isomers
IC
IB