Ho, Hon Eong Stephens, Thomas C. J. Payne, Thomas O’Brien, Peter J. K. Taylor, Richard Unsworth, William P. Merging π‑Acid and Pd Catalysis: Dearomatizing Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered Aromatics A one-pot protocol for the dearomatizing spirocyclization/cross-coupling of alkyne-tethered indoles/pyrroles is described. Mechanistic studies support a process by which palladium complexes generated in situ act as both π-acid and cross-coupling catalysts. Overall, this facilitates an efficient cascade process that enables the simultaneous preparation of synthetically challenging quaternary spirocyclic carbons and tetrasubstituted alkenes in a single operation. dearomatizing;spirocyclization;indole;one-pot protocol;cross-coupling catalysts;Alkyne-Tethered Aromatics;quaternary spirocyclic carbons;cascade process;synthetically;tetrasubstituted alkenes;alkyne-tethered;palladium complexes;π- acid;Pd Catalysis;Cascade;Merging;Dearomatizing;preparation;Spirocyclization;Mechanistic studies support 2018-12-04
    https://acs.figshare.com/articles/dataset/Merging_Acid_and_Pd_Catalysis_Dearomatizing_Spirocyclization_Cross-Coupling_Cascade_Reactions_of_Alkyne-Tethered_Aromatics/7480037
10.1021/acscatal.8b03861.s003