Merging π‑Acid and Pd Catalysis: Dearomatizing
Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered
Aromatics
Hon Eong Ho
Thomas C. Stephens
Thomas J. Payne
Peter O’Brien
Richard J. K. Taylor
William P. Unsworth
10.1021/acscatal.8b03861.s002
https://acs.figshare.com/articles/dataset/Merging_Acid_and_Pd_Catalysis_Dearomatizing_Spirocyclization_Cross-Coupling_Cascade_Reactions_of_Alkyne-Tethered_Aromatics/7480034
A one-pot
protocol for the dearomatizing spirocyclization/cross-coupling
of alkyne-tethered indoles/pyrroles is described. Mechanistic studies
support a process by which palladium complexes generated in situ act
as both π-acid and cross-coupling catalysts. Overall, this facilitates
an efficient cascade process that enables the simultaneous preparation
of synthetically challenging quaternary spirocyclic carbons and tetrasubstituted
alkenes in a single operation.
2018-12-04 00:00:00
dearomatizing
spirocyclization
indole
one-pot protocol
cross-coupling catalysts
Alkyne-Tethered Aromatics
quaternary spirocyclic carbons
cascade process
synthetically
tetrasubstituted alkenes
alkyne-tethered
palladium complexes
π- acid
Pd Catalysis
Cascade
Merging
Dearomatizing
preparation
Spirocyclization
Mechanistic studies support