Merging π‑Acid and Pd Catalysis: Dearomatizing Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered Aromatics Hon Eong Ho Thomas C. Stephens Thomas J. Payne Peter O’Brien Richard J. K. Taylor William P. Unsworth 10.1021/acscatal.8b03861.s002 https://acs.figshare.com/articles/dataset/Merging_Acid_and_Pd_Catalysis_Dearomatizing_Spirocyclization_Cross-Coupling_Cascade_Reactions_of_Alkyne-Tethered_Aromatics/7480034 A one-pot protocol for the dearomatizing spirocyclization/cross-coupling of alkyne-tethered indoles/pyrroles is described. Mechanistic studies support a process by which palladium complexes generated in situ act as both π-acid and cross-coupling catalysts. Overall, this facilitates an efficient cascade process that enables the simultaneous preparation of synthetically challenging quaternary spirocyclic carbons and tetrasubstituted alkenes in a single operation. 2018-12-04 00:00:00 dearomatizing spirocyclization indole one-pot protocol cross-coupling catalysts Alkyne-Tethered Aromatics quaternary spirocyclic carbons cascade process synthetically tetrasubstituted alkenes alkyne-tethered palladium complexes π- acid Pd Catalysis Cascade Merging Dearomatizing preparation Spirocyclization Mechanistic studies support