10.1021/acs.nanolett.8b03913.s001
Lang Rao
Lang
Rao
Wenbiao Wang
Wenbiao
Wang
Qian-Fang Meng
Qian-Fang
Meng
Mingfu Tian
Mingfu
Tian
Bo Cai
Bo
Cai
Yingchong Wang
Yingchong
Wang
Aixin Li
Aixin
Li
Minghui Zan
Minghui
Zan
Feng Xiao
Feng
Xiao
Lin-Lin Bu
Lin-Lin
Bu
Geng Li
Geng
Li
Andrew Li
Andrew
Li
Yingle Liu
Yingle
Liu
Shi-Shang Guo
Shi-Shang
Guo
Xing-Zhong Zhao
Xing-Zhong
Zhao
Tza-Huei Wang
Tza-Huei
Wang
Wei Liu
Wei
Liu
Jianguo Wu
Jianguo
Wu
A Biomimetic Nanodecoy Traps Zika Virus To Prevent
Viral Infection and Fetal Microcephaly Development
American Chemical Society
2018
Biomimetic Nanodecoy Traps Zika Virus
ND
ZIKV infection
Fetal Microcephaly Development Zika virus
gelatin nanoparticle core
mosquito medium host cell membranes
2018-12-13 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/A_Biomimetic_Nanodecoy_Traps_Zika_Virus_To_Prevent_Viral_Infection_and_Fetal_Microcephaly_Development/7473041
Zika virus (ZIKV) has emerged as
a global health threat due to
its unexpected causal link to devastating neurological disorders such
as fetal microcephaly; however, to date, no approved vaccine or specific
treatment is available for ZIKV infection. Here we develop a biomimetic
nanodecoy (ND) that can trap ZIKV, divert ZIKV away from its intended
targets, and inhibit ZIKV infection. The ND, which is composed of
a gelatin nanoparticle core camouflaged by mosquito medium host cell
membranes, effectively adsorbs ZIKV and inhibits ZIKV replication
in ZIKV-susceptible cells. Using a mouse model, we demonstrate that
NDs significantly attenuate the ZIKV-induced inflammatory responses
and degenerative changes and thus improve the survival rate of ZIKV-challenged
mice. Moreover, by trapping ZIKV, NDs successfully prevent ZIKV from
passing through physiologic barriers into the fetal brain and thereby
mitigate ZIKV-induced fetal microcephaly in pregnant mice. We anticipate
that this study will provide new insights into the development of
safe and effective protection against ZIKV and various other viruses
that threaten public health.