Qin, Tao Li, Jian-Ping Xie, Ming-Sheng Qu, Gui-Rong Guo, Hai-Ming Synthesis of Chiral Acyclic Nucleosides by Sharpless Asymmetric Dihydroxylation: Access to Cidofovir and Buciclovir An efficient method to construct chiral acyclic nucleosides via Sharpless asymmetric dihydroxylation of <i>N</i>-allylpyrimidines or <i>N</i>-alkenylpurines is reported. A range of chiral acyclic nucleosides with two adjacent hydroxyl groups present on the side chains could be produced in good yields (up to 97% yield) and excellent enantioselectivities (90–99% ee). The synthetic utility of the reaction was demonstrated by the catalytic asymmetric synthesis of (<i>S</i>)-Cidofovir and (<i>R</i>)-Buciclovir. alkenylpurine;Access;utility;synthesis;ee;dihydroxylation;side chains;method;Buciclovir;Synthesi;enantioselectivitie;Cidofovir;chiral acyclic nucleosides;hydroxyl groups;Sharpless Asymmetric Dihydroxylation;yield;Chiral Acyclic Nucleosides;allylpyrimidine 2018-11-23
    https://acs.figshare.com/articles/dataset/Synthesis_of_Chiral_Acyclic_Nucleosides_by_Sharpless_Asymmetric_Dihydroxylation_Access_to_Cidofovir_and_Buciclovir/7427480
10.1021/acs.joc.8b02442.s002