10.1021/acsbiomaterials.8b01163.s001 Yilong Cheng Yilong Cheng Gary W. Liu Gary W. Liu Ritika Jain Ritika Jain Jeffrey W. Pippin Jeffrey W. Pippin Stuart J. Shankland Stuart J. Shankland Suzie H. Pun Suzie H. Pun Boronic Acid Copolymers for Direct Loading and Acid-Triggered Release of Bis-T-23 in Cultured Podocytes American Chemical Society 2018 acid-reversible phenylboronic acid-containing polymers kidney disease treatment covalent boronate ester bond solubilize Bis-T -23. Bis-T -23 boronic ester bond podocyte 2018-11-23 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Boronic_Acid_Copolymers_for_Direct_Loading_and_Acid-Triggered_Release_of_Bis-T-23_in_Cultured_Podocytes/7396739 We report an acid-reversible linker for triggered release of Bis-T-23, an experimental small molecule drug for kidney disease treatment that restores podocyte morphology during disease. Bis-T-23 contains catechols, which form an acid-reversible, covalent boronate ester bond with boronic acids. We synthesized phenylboronic acid-containing polymers using reversible addition–fragmentation chain transfer polymerization that were able to directly load and solubilize Bis-T-23. Because of the reversibility of the boronic ester bond, drug was released in its native form in a pH-dependent manner. The polymers rapidly trafficked into acidic compartments and did not exhibit cytotoxicity, and polymer-drug conjugates successfully delivered Bis-T-23 into cultured podocytes.