%0 Journal Article
%A Chen, Sujun
%A Wang, Yichuan
%A Nie, Ting
%A Bao, Chunyan
%A Wang, Chenxi
%A Xu, Tianyi
%A Lin, Qiuning
%A Qu, Da-Hui
%A Gong, Xueqing
%A Yang, Yi
%A Zhu, Linyong
%A Tian, He
%D 2018
%T An Artificial
Molecular Shuttle Operates in Lipid
Bilayers for Ion Transport
%U https://acs.figshare.com/articles/journal_contribution/An_Artificial_Molecular_Shuttle_Operates_in_Lipid_Bilayers_for_Ion_Transport/7393286
%R 10.1021/jacs.8b09580.s001
%2 https://acs.figshare.com/ndownloader/files/13677524
%K Artificial Molecular Shuttle Operates
%K EC 50 value
%K shuttle
%K rotaxane
%K ion
%K macrocycle wheel component
%K lipid bilayers
%X Inspired
by natural biomolecular machines, synthetic molecular-level
machines have been proven to perform well-defined mechanical tasks
and measurable work. To mimic the function of channel proteins, we
herein report the development of a synthetic molecular shuttle, [2]rotaxane 3, as a unimolecular vehicle that can be inserted
into lipid bilayers to perform passive ion transport through its stochastic
shuttling motion. The [2]rotaxane molecular shuttle is composed of
an amphiphilic molecular thread with three binding stations, which
is interlocked in a macrocycle wheel component that tethers a K+ carrier. The structural characteristics enable the rotaxane
to transport ions across the lipid bilayers, similar to a cable car,
transporting K+ with an EC50 value of 1.0 μM
(3.0 mol % relative to lipid). We expect that this simple molecular
machine will provide new opportunities for developing more effective
and selective ion transporters.
%I ACS Publications