%0 Journal Article %A Chen, Junjie %A Han, Xiuling %A Lu, Xiyan %D 2018 %T Palladium(II)-Catalyzed Asymmetric Tandem Cyclization of 2‑Aminoaryl Alkynones: An Approach to Chiral 1,2,3,4-Tetrahydro-β-carbolines %U https://acs.figshare.com/articles/journal_contribution/Palladium_II_-Catalyzed_Asymmetric_Tandem_Cyclization_of_2_Aminoaryl_Alkynones_An_Approach_to_Chiral_1_2_3_4-Tetrahydro-_-carbolines/7392842 %R 10.1021/acs.orglett.8b03247.s001 %2 https://acs.figshare.com/ndownloader/files/13675970 %K Cyclization %K carbonyl group tandem processes %K Alkynone %K Pd %K Approach %K Tetrahydro %K Asymmetric %K 2- alkynylaniline derivatives %K cyclization %K strategy %K access %K Palladium %K Chiral %K Aminoaryl %K material %K tetrahydro %K yield %K aminopalladation %K catalyst %K 2- aminoaryl alkynones %K palladium %K chiral %K alkyne %K -β-carboline %K intramolecular trans %K enantioselectivitie %K Tandem %X A Pd­(OAc)2-catalyzed asymmetric cyclization of 2-aminoaryl alkynones involving an intramolecular trans-aminopalladation of alkyne and 1,2-addition to the carbonyl group tandem processes was developed. This strategy represents the first example using palladium as the catalyst and 2-alkynylaniline derivatives as the starting material to allow facile access to chiral 1,2,3,4-tetrahydro-β-carbolines in high yields and excellent enantioselectivities. %I ACS Publications