%0 Journal Article
%A Chen, Junjie
%A Han, Xiuling
%A Lu, Xiyan
%D 2018
%T Palladium(II)-Catalyzed Asymmetric Tandem Cyclization
of 2‑Aminoaryl Alkynones: An Approach to Chiral 1,2,3,4-Tetrahydro-β-carbolines
%U https://acs.figshare.com/articles/journal_contribution/Palladium_II_-Catalyzed_Asymmetric_Tandem_Cyclization_of_2_Aminoaryl_Alkynones_An_Approach_to_Chiral_1_2_3_4-Tetrahydro-_-carbolines/7392842
%R 10.1021/acs.orglett.8b03247.s001
%2 https://acs.figshare.com/ndownloader/files/13675970
%K Cyclization
%K carbonyl group tandem processes
%K Alkynone
%K Pd
%K Approach
%K Tetrahydro
%K Asymmetric
%K 2- alkynylaniline derivatives
%K cyclization
%K strategy
%K access
%K Palladium
%K Chiral
%K Aminoaryl
%K material
%K tetrahydro
%K yield
%K aminopalladation
%K catalyst
%K 2- aminoaryl alkynones
%K palladium
%K chiral
%K alkyne
%K -β-carboline
%K intramolecular trans
%K enantioselectivitie
%K Tandem
%X A Pd(OAc)2-catalyzed asymmetric cyclization of 2-aminoaryl
alkynones involving an intramolecular trans-aminopalladation
of alkyne and 1,2-addition to the carbonyl group tandem processes
was developed. This strategy represents the first example using palladium
as the catalyst and 2-alkynylaniline derivatives as the starting material
to allow facile access to chiral 1,2,3,4-tetrahydro-β-carbolines
in high yields and excellent enantioselectivities.
%I ACS Publications