Substrate-Controlled Domino Reactions of Crotonate-Derived Sulfur Ylides: Synthesis of Benzothiophene Derivatives Wenhuan Ding Youquan Zhang Aimin Yu Lei Zhang Xiangtai Meng 10.1021/acs.joc.8b02152.s002 https://acs.figshare.com/articles/dataset/Substrate-Controlled_Domino_Reactions_of_Crotonate-Derived_Sulfur_Ylides_Synthesis_of_Benzothiophene_Derivatives/7316231 Substrate-controlled domino reactions between thioaurones or their analogues and crotonate-derived sulfur ylides were developed and produced a broad spectrum of benzothiophene-fused pyran derivatives, substituted chromene derivatives. In these reactions, crotonate-derived sulfur ylides acting as two-carbon synthons (α and β carbons or β and γ carbons) in annulation reactions are reported for the first time. These investigations nicely complement and expand previously studied reactions of crotonate-derived sulfur ylides. In addition, reaction mechanisms for these domino reactions are proposed, one of which is supported by DFT calculations. 2018-10-29 00:00:00 annulation reactions γ carbons reaction mechanisms domino reactions β carbons chromene derivatives DFT calculations Substrate-Controlled Domino Reactions crotonate-derived sulfur ylides Crotonate-Derived Sulfur Ylides Benzothiophene Derivatives Substrate-controlled domino reactions benzothiophene-fused pyran derivatives