Substrate-Controlled
Domino Reactions of Crotonate-Derived Sulfur Ylides: Synthesis of
Benzothiophene Derivatives
Wenhuan Ding
Youquan Zhang
Aimin Yu
Lei Zhang
Xiangtai Meng
10.1021/acs.joc.8b02152.s002
https://acs.figshare.com/articles/dataset/Substrate-Controlled_Domino_Reactions_of_Crotonate-Derived_Sulfur_Ylides_Synthesis_of_Benzothiophene_Derivatives/7316231
Substrate-controlled domino reactions
between thioaurones or their analogues and crotonate-derived sulfur
ylides were developed and produced a broad spectrum of benzothiophene-fused
pyran derivatives, substituted chromene derivatives. In these reactions,
crotonate-derived sulfur ylides acting as two-carbon synthons (α
and β carbons or β and γ carbons) in annulation
reactions are reported for the first time. These investigations nicely
complement and expand previously studied reactions of crotonate-derived
sulfur ylides. In addition, reaction mechanisms for these domino reactions
are proposed, one of which is supported by DFT calculations.
2018-10-29 00:00:00
annulation reactions
γ carbons
reaction mechanisms
domino reactions
β carbons
chromene derivatives
DFT calculations
Substrate-Controlled Domino Reactions
crotonate-derived sulfur ylides
Crotonate-Derived Sulfur Ylides
Benzothiophene Derivatives Substrate-controlled domino reactions
benzothiophene-fused pyran derivatives