Catalytic Asymmetric Mannich Type Reaction with Tri-/Difluoro- or Trichloroacetaldimine Precursors YouYang’en LuoSanzhong 2018 A highly efficient catalytic asymmetric Mannich type reaction of CF<sub>3</sub>-<sub>,</sub> CF<sub>2</sub>H-, or CCl<sub>3</sub>-acetaldimine precursors by a chiral primary amine is presented. This protocol provides facile access to chiral CF<sub>3</sub>-, CF<sub>2</sub>H-, or trichloroethyl amines in excellent yields and high enantioselectivity (up to 99% yield, up to >99% ee).