Peng, Xing-Rong Huang, Yan-Jie Lu, Shuang-Yang Yang, Jing Qiu, Ming-Hua Ganolearic Acid A, a Hexanorlanostane Triterpenoid with a 3/5/6/5-Fused Tetracyclic Skeleton from Ganoderma cochlear Ganolearic acid A (<b>1</b>), a 3,4-<i>seco</i>-hexanortriterpenoid featuring a rare 3/5/6/5 tetracyclic system, was obtained in trace amounts from Ganoderma cochlear by a LC-UV/MS-guided method. Meanwhile, a new 3,4-<i>seco</i>-nortriterpenoid, fornicatin M (<b>2</b>), as well as its biogenetic precursor, fornicatin D (<b>3</b>), was isolated. The stereochemical structure of <b>1</b> was completely established by 1D, 2D NMR, IR, and HRMS spectra, as well as <sup>13</sup>C NMR and electronic circular dichroism calculations. The plausible biogenetic pathway of <b>1</b> and <b>2</b> was proposed. Furthermore, their anti-inflammatory activities were evaluated. Ganoderma cochlear Ganolearic acid;Fused;fornicatin M;anti-inflammatory activities;Hexanorlanostane Triterpenoid;fornicatin D;seco;dichroism calculations;hexanortriterpenoid;13 C NMR;1 D;Ganoderma cochlear;LC-UV;IR;Tetracyclic;biogenetic pathway;biogenetic precursor;stereochemical structure;Skeleton;HRMS spectra;trace amounts;nortriterpenoid;tetracyclic;method;2 D NMR 2018-10-22
    https://acs.figshare.com/articles/journal_contribution/Ganolearic_Acid_A_a_Hexanorlanostane_Triterpenoid_with_a_3_5_6_5-Fused_Tetracyclic_Skeleton_from_Ganoderma_cochlear/7235288
10.1021/acs.joc.8b01906.s001