Ganolearic Acid A, a Hexanorlanostane Triterpenoid with a 3/5/6/5-Fused Tetracyclic Skeleton from Ganoderma cochlear PengXing-Rong HuangYan-Jie LuShuang-Yang YangJing QiuMing-Hua 2018 Ganolearic acid A (<b>1</b>), a 3,4-<i>seco</i>-hexanortriterpenoid featuring a rare 3/5/6/5 tetracyclic system, was obtained in trace amounts from Ganoderma cochlear by a LC-UV/MS-guided method. Meanwhile, a new 3,4-<i>seco</i>-nortriterpenoid, fornicatin M (<b>2</b>), as well as its biogenetic precursor, fornicatin D (<b>3</b>), was isolated. The stereochemical structure of <b>1</b> was completely established by 1D, 2D NMR, IR, and HRMS spectra, as well as <sup>13</sup>C NMR and electronic circular dichroism calculations. The plausible biogenetic pathway of <b>1</b> and <b>2</b> was proposed. Furthermore, their anti-inflammatory activities were evaluated.