Kao, Tzu-Ting Peng, Bo-Kai Liang, Min-Chieh Lee, Chia-Jui Chen, I-Chia Shia, Kak-Shan Wu, Yen-Ku Temperature-Controlled Thiation of α‑Cyano-β-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2‑Aminothiophenes and Thieno[2,3‑<i>c</i>]isothiazoles Making use of temperature-controlled thiation as a key operation, a simple route to 2-aminothiophenes or thieno­[2,3-<i>c</i>]­isothiazoles has been newly developed wherein the 2-aminothiophene nucleus was formed through an initial formation of thioamide followed by a 5-exo-dig addition to the tethered alkyne; however, under harsher thermal conditions, excess sulfur-transferring reagents enabled further oxidative thiation to generate the corresponding thieno­[2,3-<i>c</i>]­isothiazoles. De Novo Synthesis;oxidative thiation;2- aminothiophene nucleus;temperature-controlled thiation;5- exo-dig addition;sulfur-transferring reagents;2- aminothiophenes;isothiazole;Temperature-Controlled Thiation;thieno 2018-10-02
    https://acs.figshare.com/articles/journal_contribution/Temperature-Controlled_Thiation_of_Cyano-_-Alkynyl_Carbonyl_Derivatives_for_De_Novo_Synthesis_of_2_Aminothiophenes_and_Thieno_2_3_i_c_i_isothiazoles/7201556
10.1021/acs.joc.8b01866.s001