Colorimetric Calcium Probe with Comparison to an Ion-Selective
Optode
Changyou Zhu
Manling Huang
Jialing Lan
Lung Wa Chung
Xin Li
Xiaojiang Xie
10.1021/acsomega.8b01813.s001
https://acs.figshare.com/articles/journal_contribution/Colorimetric_Calcium_Probe_with_Comparison_to_an_Ion-Selective_Optode/7159646
Design strategies for small molecular
probes lay the foundation
of numerous synthetic chemosensors. A water-soluble colorimetric calcium
molecular probe inspired by the ionophore-based ion-selective optode
is presented here with a tunable detection range (around micromolar
at pH 7). The binding of Ca<sup>2+</sup> resulted in the deprotonation
of the probe and thus a significant spectral change, mimicking the
ion-exchange process in ion-selective optodes. The 1:1 exchange between
Ca<sup>2+</sup> and H<sup>+</sup> was confirmed with Job’s
plot. Computational studies revealed possible monomer and dimer forms
of the probe–Ca<sup>2+</sup> complexes.
2018-10-03 08:13:36
probe
colorimetric calcium
ion-exchange process
dimer forms
Computational studies
tunable detection range
Ion-Selective Optode Design strategies
ion-selective optodes
Colorimetric Calcium Probe
ionophore-based ion-selective optode