10.1021/acs.orglett.8b02668.s001
Jialin Ming
Jialin
Ming
Tamio Hayashi
Tamio
Hayashi
Rhodium-Catalyzed Arylzincation of Alkynes: Ligand
Control of 1,4‑Migration Selectivity
American Chemical Society
2018
rhodium complexes
arylzinc reagents ArZnCl 1
zinc chloride
migration
ligand
presence
Rhodium-Catalyzed Arylzincation
binap
Alkyne
2- arylalkenylzinc species 3
Ligands cod
selectivity
Ligand Control
Selectivity
ortho
Migration
alkynes 2
alkenylarylzinc species 4
latter
2018-09-20 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Rhodium-Catalyzed_Arylzincation_of_Alkynes_Ligand_Control_of_1_4_Migration_Selectivity/7111202
The addition of arylzinc
reagents ArZnCl <b>1</b> to alkynes <b>2</b> was found
to be catalyzed by rhodium complexes in the presence
of a catalytic amount of zinc chloride. The selectivity in giving
2-arylalkenylzinc species <b>3</b> or <i>ortho</i>-alkenylarylzinc species <b>4</b>, the latter of which is generated
through 1,4-Rh migration from alkenyl to aryl in the catalytic cycle,
is controlled by the ligands on rhodium. Ligands cod and binap gave <b>3</b> and <b>4</b>, respectively, with high selectivity.