%0 Journal Article %A Zhang, Yu-Bo %A Yang, Li %A Luo, Ding %A Chen, Neng-Hua %A Wu, Zhong-Nan %A Ye, Wen-Cai %A Li, Yao-Lan %A Wang, Guo-Cai %D 2018 %T Sophalines Eā€“I, Five Quinolizidine-Based Alkaloids with Antiviral Activities against the Hepatitis B Virus from the Seeds of Sophora alopecuroides %U https://acs.figshare.com/articles/journal_contribution/Sophalines_E_I_Five_Quinolizidine-Based_Alkaloids_with_Antiviral_Activities_against_the_Hepatitis_B_Virus_from_the_Seeds_of_i_Sophora_alopecuroides_i_/7074746 %R 10.1021/acs.orglett.8b02637.s001 %2 https://acs.figshare.com/ndownloader/files/13007921 %K Compound 2 %K novel quinolizidine-based alkaloids %K single-crystal X-ray diffraction %K Hepatitis B Virus %K Compounds 1 %K Quinolizidine-Based Alkaloids %K Hypothetical biosynthetic pathways %K Sophora alopecuroides %K Sophora alopecuroides L %K Antiviral Activities %K epimeric normatrine-julolidine alkaloids %K hepatitis B virus %K matrine-indolizine alkaloids %K spectroscopic methods %K dichroism analyses %X Five novel quinolizidine-based alkaloids (1ā€“5) were obtained from the seeds of Sophora alopecuroides L. Compounds 1 and 2 are the first examples of sparteine-indolizine and matrine-indolizine alkaloids, respectively, whereas 3 and 4 are epimeric normatrine-julolidine alkaloids with unusual skeletons. The structures of these compounds were determined by spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism analyses. Hypothetical biosynthetic pathways of 1ā€“5 were proposed. Compound 2 exhibited significant antiviral activity against the hepatitis B virus. %I ACS Publications