%0 Journal Article
%A Zhang, Yu-Bo
%A Yang, Li
%A Luo, Ding
%A Chen, Neng-Hua
%A Wu, Zhong-Nan
%A Ye, Wen-Cai
%A Li, Yao-Lan
%A Wang, Guo-Cai
%D 2018
%T Sophalines EāI, Five Quinolizidine-Based Alkaloids
with Antiviral Activities against the Hepatitis B Virus from the Seeds
of Sophora alopecuroides
%U https://acs.figshare.com/articles/journal_contribution/Sophalines_E_I_Five_Quinolizidine-Based_Alkaloids_with_Antiviral_Activities_against_the_Hepatitis_B_Virus_from_the_Seeds_of_i_Sophora_alopecuroides_i_/7074746
%R 10.1021/acs.orglett.8b02637.s001
%2 https://acs.figshare.com/ndownloader/files/13007921
%K Compound 2
%K novel quinolizidine-based alkaloids
%K single-crystal X-ray diffraction
%K Hepatitis B Virus
%K Compounds 1
%K Quinolizidine-Based Alkaloids
%K Hypothetical biosynthetic pathways
%K Sophora alopecuroides
%K Sophora alopecuroides L
%K Antiviral Activities
%K epimeric normatrine-julolidine alkaloids
%K hepatitis B virus
%K matrine-indolizine alkaloids
%K spectroscopic methods
%K dichroism analyses
%X Five novel quinolizidine-based
alkaloids (1ā5) were obtained from
the seeds of Sophora alopecuroides L. Compounds 1 and 2 are the first examples
of sparteine-indolizine and matrine-indolizine alkaloids, respectively,
whereas 3 and 4 are epimeric normatrine-julolidine
alkaloids with unusual skeletons. The structures of these compounds
were determined by spectroscopic methods, single-crystal X-ray diffraction,
and electronic circular dichroism analyses. Hypothetical biosynthetic
pathways of 1ā5 were proposed. Compound 2 exhibited significant antiviral activity against the hepatitis
B virus.
%I ACS Publications