10.1021/acscatal.8b02661.s002
Hai-Jie Song
Hai-Jie
Song
Wei-Tao Jiang
Wei-Tao
Jiang
Qiao-Lan Zhou
Qiao-Lan
Zhou
Meng-Yu Xu
Meng-Yu
Xu
Bin Xiao
Bin
Xiao
Structure-Modified Germatranes for Pd-Catalyzed Biaryl
Synthesis
American Chemical Society
2018
germatrane
nucleophilic fragments
Pd-catalyzed germylation
Ge-containing nucleophiles
Grignard reagents
aryl halides
Structure-Modified Germatranes
GeO 2
cross-coupling reactivity
Pd-Catalyzed Biaryl Synthesis Germanium
2018-09-04 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Structure-Modified_Germatranes_for_Pd-Catalyzed_Biaryl_Synthesis/7059068
Germanium,
a member of 14th group that falls between Si and Sn,
has remained considerably ignored as a nucleophile for a long time.
Compared with other forms of Ge-containing nucleophiles, germatranes
are structure-defined, easily accessible, and stabilized nucleophilic
fragments, but they fail to meet the need of high reactivity and facile
introducing to organics. Herein, we report a modified structure of
germatranes, whose cross-coupling reactivity is greatly improved.
The structure can be easily constructed from inexpensive industrial
GeO<sub>2</sub>, and corresponding <b><i>Ge</i></b>-Cl and <b><i>Ge</i></b>-H can also be obtained after
facile transformations. Moreover, Ar-<b><i>Ge</i></b> can be effectively synthesized either from Grignard reagents or
Pd-catalyzed germylation of aryl halides.