10.1021/acs.jpcc.8b06117.s001
Raju R. Kumal
Raju R.
Kumal
Mohammad Abu-Laban
Mohammad
Abu-Laban
Prakash Hamal
Prakash
Hamal
Blake Kruger
Blake
Kruger
Holden T. Smith
Holden T.
Smith
Daniel J. Hayes
Daniel J.
Hayes
Louis H. Haber
Louis H.
Haber
Near-Infrared Photothermal Release of siRNA from the
Surface of Colloidal Gold–Silver–Gold Core–Shell–Shell
Nanoparticles Studied with Second-Harmonic Generation
American Chemical Society
2018
CSS nanoparticles
photothermal cleaving kinetics
NIR laser powers
photothermal cleaving linkers
SHG
Second-Harmonic Generation Photothermal release
plasmonic CSS nanoparticles
plasmonic nanoparticles
Near-Infrared Photothermal Release
photothermal cleaving
surface-sensitive time-dependent second-harmonic generation
GNP
nanoparticle-based NIR-mediated
gold nanoparticles
bind siRNA
photothermal release
drug delivery
nanoparticle surface
2018-08-06 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Near-Infrared_Photothermal_Release_of_siRNA_from_the_Surface_of_Colloidal_Gold_Silver_Gold_Core_Shell_Shell_Nanoparticles_Studied_with_Second-Harmonic_Generation/6981536
Photothermal release
of oligonucleotides from the surface of plasmonic
nanoparticles represents a promising platform for spatiotemporal controlled
drug delivery. Here we demonstrate the use of novel gold–silver–gold
core–shell–shell (CSS) nanoparticles to study the photothermal
cleaving and release of micro-RNA (miRNA) mimics or small interfering
RNA (siRNA) under near-infrared (NIR) irradiation. The furan–maleimide-based
Diels–Alder adduct cleaves thermally above 60 °C and is
used to bind siRNA to the colloidal nanoparticle surface in water.
We investigate the photothermal cleaving kinetics of siRNA under different
NIR laser powers using surface-sensitive time-dependent second-harmonic
generation (SHG) spectroscopy. The photothermal release of siRNA
from the surface of CSS nanoparticles is significantly higher than
that from the surface of gold nanoparticles (GNPs) under similar experimental
conditions. These results demonstrate that plasmonic CSS nanoparticles
with photothermal cleaving linkers have important potential applications
for nanoparticle-based NIR-mediated drug-delivery systems.