Synthesis of Enantioenriched α,α-Dichloro- and α,α-Difluoro-β-Hydroxy Esters and Amides by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation Long-Sheng Zheng Phannarath Phansavath Virginie Ratovelomanana-Vidal 10.1021/acs.orglett.8b01943.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Enantioenriched_-Dichloro-_and_-Difluoro-_-Hydroxy_Esters_and_Amides_by_Ruthenium-Catalyzed_Asymmetric_Transfer_Hydrogenation/6953141 A mild and convenient approach was developed to prepare a series of α,α-dihalogeno β-hydroxy esters or amides by using commercially available Noyori’s complex [RuCl­(<i>p</i>-cymene)­(<i>R</i>,<i>R</i>)-TsDPEN] as a catalyst (S/C = 100−200) in the asymmetric transfer hydrogenation of the corresponding ketones. Moderate to high yields (up to 99%) and excellent enantioselectivities (up to >99% ee) were achieved for a series of variously substituted dichloro and difluoro β-hydroxy esters and amides. 2018-08-09 19:39:04 enantioselectivitie TsDPEN dihalogeno cymene difluoro β- hydroxy esters Ester Moderate -β-Hydroxy ee series approach Synthesi Amide Dichloro Noyori catalyst Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation amide Difluoro yield transfer hydrogenation ketone RuCl dichloro Enantioenriched