10.1021/acs.orglett.8b01943.s001
Long-Sheng Zheng
Long-Sheng
Zheng
Phannarath Phansavath
Phannarath
Phansavath
Virginie Ratovelomanana-Vidal
Virginie
Ratovelomanana-Vidal
Synthesis of Enantioenriched α,α-Dichloro-
and α,α-Difluoro-β-Hydroxy Esters and Amides by
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation
American Chemical Society
2018
enantioselectivitie
TsDPEN
dihalogeno
cymene
difluoro β- hydroxy esters
Ester
Moderate
-β-Hydroxy
ee
series
approach
Synthesi
Amide
Dichloro
Noyori
catalyst
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation
amide
Difluoro
yield
transfer hydrogenation
ketone
RuCl
dichloro
Enantioenriched
2018-08-09 19:39:04
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Enantioenriched_-Dichloro-_and_-Difluoro-_-Hydroxy_Esters_and_Amides_by_Ruthenium-Catalyzed_Asymmetric_Transfer_Hydrogenation/6953141
A mild and convenient approach was
developed to prepare a series
of α,α-dihalogeno β-hydroxy esters or amides by
using commercially available Noyori’s complex [RuCl(<i>p</i>-cymene)(<i>R</i>,<i>R</i>)-TsDPEN]
as a catalyst (S/C = 100−200) in the asymmetric transfer hydrogenation
of the corresponding ketones. Moderate to high yields (up to 99%)
and excellent enantioselectivities (up to >99% ee) were achieved
for
a series of variously substituted dichloro and difluoro β-hydroxy
esters and amides.