Yu, Xiaoqiang Gao, Linqi Jia, Linan Yamamoto, Yoshinori Bao, Ming Synthesis of Quinazolin-4(3<i>H</i>)‑ones via the Reaction of 2‑Halobenzamides with Nitriles This paper describes a convenient method to synthesize quinazolin-4­(3<i>H</i>)-ones from simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed nucleophilic addition of 2-halobenzamide to nitriles followed by S<sub>N</sub>Ar reaction proceeds smoothly in the presence of <sup><i>t</i></sup>BuOK as a base to produce quinazolinone derivatives. quinazolinone derivatives;2- halobenzamide;presence;S N Ar reaction proceeds;2- halobenzamides;Lewis acid Cu-catalyzed nucleophilic addition;Nitrile;method;Synthesi;t BuOK;nitrile;Quinazolin;Halobenzamide 2018-08-07
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Quinazolin-4_3_i_H_i_ones_via_the_Reaction_of_2_Halobenzamides_with_Nitriles/6940751
10.1021/acs.joc.8b01460.s001