10.1021/acsnano.7b07439.s004
Weizong Weng
Weizong
Weng
Sisi He
Sisi
He
Hongyuan Song
Hongyuan
Song
Xiaoqun Li
Xiaoqun
Li
Liehu Cao
Liehu
Cao
Yajie Hu
Yajie
Hu
Jin Cui
Jin
Cui
Qirong Zhou
Qirong
Zhou
Huisheng Peng
Huisheng
Peng
Jiacan Su
Jiacan
Su
Aligned Carbon Nanotubes Reduce Hypertrophic Scar <i>via</i> Regulating Cell Behavior
American Chemical Society
2018
gene expression microarray
TGF β pathway
cell proliferation
chemical vapor deposition
Regulating Cell Behavior Hypertrophic scars
hypertrophic scar formation
Aligned Carbon Nanotubes
ACNT
rabbit ear model
carbon nanotubes
2018-07-24 00:00:00
Media
https://acs.figshare.com/articles/media/Aligned_Carbon_Nanotubes_Reduce_Hypertrophic_Scar_i_via_i_Regulating_Cell_Behavior/6869591
Hypertrophic
scars, characterized by excessive cell proliferation,
disordered cell growth, and aberrant deposition of collagens, could
cause significant clinical problems. Herein, aligned carbon nanotubes
(ACNTs) were synthesized <i>via</i> chemical vapor deposition,
and bulk ACNTs were pulled out from the arrays. The capacity of the
ACNTs to reduce hypertrophic scar formation was evaluated both <i>in vitro</i> and <i>in vivo</i>. The results demonstrated
that the ACNTs suppressed the overproliferation of fibroblast cells,
directed their growth, and inhibited collagen expression <i>in
vitro</i> without cell cytotoxicity. Moreover, <i>in vivo</i> evaluation in a rabbit ear model indicated relieved scar hypertrophy
after the ACNTs treatment. The gene expression microarray was further
used to understand the mechanism, which showed that ACNTs could inhibit
the TGFβ pathway to alter the components in the extracellular
matrix, cell proliferation, cell cytoskeleton, and cell motility.
These findings may provide a potent strategy of using carbon nanotubes
in the bioengineering field.