Sharma, Brijesh M. Rathod, Jayant Gonnade, Rajesh G. Kumar, Pradeep Harnessing Nucleophilicity of Allenol Ester with <i>p-</i>Quinone Methides via Gold Catalysis: Application to the Synthesis of Diarylmethine-Substituted Enones A gold­(I)-catalyzed protocol for intermolecular 1,6-conjugate addition of nucleophilic allenol ester generated in situ through [3,3]-sigmatropic rearrangement with <i>p</i>-quinone methides (<i>p</i>-QMs) has been developed. The gold catalyst plays a dual role by the π-acid-triggered activation of alkynes and at the same time as a Lewis acid for activation of <i>p</i>-QMs toward nucleophilic attack. This method enables rapid access to a wide range of densely functionalized diarylmethine-substituted enones, a Morita-Baylis-Hillman (MBH) product with high selectivity, excellent yields, and broad substrate scope. Lewis acid;selectivity;functionalized diarylmethine-substituted enones;Application;Quinone Methides;gold catalyst;conjugate;Allenol Ester;nucleophilic attack;π- acid-triggered activation;substrate scope;sigmatropic;Morita-Baylis-Hillman;Nucleophilicity;Gold Catalysis;access;nucleophilic allenol ester;role;Synthesi;yield;rearrangement;quinone methides;MBH;method;alkyne;Diarylmethine-Substituted Enones;QM 2018-06-20
    https://acs.figshare.com/articles/dataset/Harnessing_Nucleophilicity_of_Allenol_Ester_with_i_p-_i_Quinone_Methides_via_Gold_Catalysis_Application_to_the_Synthesis_of_Diarylmethine-Substituted_Enones/6743558
10.1021/acs.joc.8b01294.s002