Enantioselective Cobalt-Catalyzed Sequential Nazarov
Cyclization/Electrophilic Fluorination: Access to Chiral α‑Fluorocyclopentenones
Heyi Zhang
Biao Cheng
Zhan Lu
10.1021/acs.orglett.8b01597.s001
https://acs.figshare.com/articles/journal_contribution/Enantioselective_Cobalt-Catalyzed_Sequential_Nazarov_Cyclization_Electrophilic_Fluorination_Access_to_Chiral_Fluorocyclopentenones/6621320
A newly
designed thiazoline iminopyridine ligand for enantioselective
cobalt-catalyzed sequential Nazarov cyclization/electrophilic fluorination
was developed. Various chiral α-fluorocyclopentenones were prepared
with good yields and diastereo- and enantioselectivities. Further
derivatizations could be easily carried out to provide chiral cyclopentenols
with three contiguous stereocenters. Furthermore, a direct deesterification
of fluorinated products could afford chiral α-single fluorine-substituted
cyclopentenones.
2018-06-20 13:54:43
Nazarov
thiazoline iminopyridine ligand
chiral cyclopentenols
fluorine-substituted cyclopentenones
chiral α-
Various chiral α- fluorocyclopentenones