Enantioselective Cobalt-Catalyzed Sequential Nazarov Cyclization/Electrophilic Fluorination: Access to Chiral α‑Fluorocyclopentenones Heyi Zhang Biao Cheng Zhan Lu 10.1021/acs.orglett.8b01597.s001 https://acs.figshare.com/articles/journal_contribution/Enantioselective_Cobalt-Catalyzed_Sequential_Nazarov_Cyclization_Electrophilic_Fluorination_Access_to_Chiral_Fluorocyclopentenones/6621320 A newly designed thiazoline iminopyridine ligand for enantioselective cobalt-catalyzed sequential Nazarov cyclization/electrophilic fluorination was developed. Various chiral α-fluorocyclopentenones were prepared with good yields and diastereo- and enantioselectivities. Further derivatizations could be easily carried out to provide chiral cyclopentenols with three contiguous stereocenters. Furthermore, a direct deesterification of fluorinated products could afford chiral α-single fluorine-substituted cyclopentenones. 2018-06-20 13:54:43 Nazarov thiazoline iminopyridine ligand chiral cyclopentenols fluorine-substituted cyclopentenones chiral α- Various chiral α- fluorocyclopentenones