%0 Journal Article %A Xiao, Ruiqing %A Zeng, Jialiu %A Grinstaff, Mark W. %D 2018 %T Biologically Active Branched Polysaccharide Mimetics: Synthesis via Ring-Opening Polymerization of a Maltose-Based β‑Lactam %U https://acs.figshare.com/articles/journal_contribution/Biologically_Active_Branched_Polysaccharide_Mimetics_Synthesis_via_Ring-Opening_Polymerization_of_a_Maltose-Based_Lactam/6513005 %R 10.1021/acsmacrolett.8b00302.s001 %2 https://acs.figshare.com/ndownloader/files/11981144 %K α- glucopyranose branches %K weight polymers %K Turbidimetric assay %K Mal-PAS %K ring-opening polymerization %K maltose-based β- lactam monomer %K Branched Polysaccharide Mimetics %K lectin Concanavalin %K helical conformation %K Ring-Opening Polymerization %X Stereoregular poly-amido-saccharides bearing α-glucopyranose branches (Mal-PASs) are synthesized by anionic ring-opening polymerization of a maltose-based β-lactam monomer followed by debenzylation. The polymerization affords high molecular weight polymers (up to 31500 g/mol) with narrow dispersities (Đ < 1.1). Deprotected Mal-PASs are highly soluble in water and adopt a left-handed helical conformation in solution. Turbidimetric assay shows that Mal-PASs are multivalent ligands to lectin Concanavalin A. %I ACS Publications