A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions Jinlong Zhao Songtao Niu Xi Jiang Yongwen Jiang Xiaojing Zhang Tiemin Sun Dawei Ma 10.1021/acs.joc.8b00888.s001 https://acs.figshare.com/articles/journal_contribution/A_Class_of_Amide_Ligands_Enable_Cu-Catalyzed_Coupling_of_Hetero_aryl_Halides_with_Sulfinic_Acid_Salts_under_Mild_Conditions/6387374 The amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline is a powerful ligand for Cu-catalyzed coupling of (hetero)­aryl halides with sulfinic acid salts, allowing the formation of a wide range of (hetero)­aryl sulfones from the corresponding (hetero)­aryl halides at considerably low catalytic loadings. The coupling of (hetero)­aryl iodides and sodium methanesulfinate proceeds at room temperature with only 0.5 mol % CuI and ligand, representing the first example for Cu-catalyzed arylation at both low catalytic loading and room temperature. 2018-05-22 00:00:00 halides Amide Ligands Enable Cu-Catalyzed ligand hetero Cu-catalyzed loading sulfinic acid salts sodium methanesulfinate proceeds room temperature