A Class of Amide Ligands
Enable Cu-Catalyzed Coupling
of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions
Jinlong Zhao
Songtao Niu
Xi Jiang
Yongwen Jiang
Xiaojing Zhang
Tiemin Sun
Dawei Ma
10.1021/acs.joc.8b00888.s001
https://acs.figshare.com/articles/journal_contribution/A_Class_of_Amide_Ligands_Enable_Cu-Catalyzed_Coupling_of_Hetero_aryl_Halides_with_Sulfinic_Acid_Salts_under_Mild_Conditions/6387374
The
amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline
is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides
with sulfinic acid salts, allowing the formation of a wide range of
(hetero)aryl sulfones from the corresponding (hetero)aryl halides
at considerably low catalytic loadings. The coupling of (hetero)aryl
iodides and sodium methanesulfinate proceeds at room temperature with
only 0.5 mol % CuI and ligand, representing the first example for
Cu-catalyzed arylation at both low catalytic loading and room temperature.
2018-05-22 00:00:00
halides
Amide Ligands Enable Cu-Catalyzed
ligand
hetero
Cu-catalyzed
loading
sulfinic acid salts
sodium methanesulfinate proceeds
room temperature