Total Synthesis of the Marine Macrolide Amphidinolide F Laurent Ferrié Johan Fenneteau Bruno Figadère 10.1021/acs.orglett.8b01020.s001 https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Marine_Macrolide_Amphidinolide_F/6270287 A new and efficient convergent approach toward the synthesis of amphidinolide F is described through the assembly of three fragments. The two <i>trans</i>-tetrahydrofurans were built by a diastereoselective <i>C</i>-glycosylation with titanium enolate of bulky <i>N</i>-acetyloxazolidinethiones. The side chain was inserted by a Liebeskind–Srogl cross-coupling reaction. A sulfone condensation/desulfonylation sequence, a Stille cross-coupling, and a macrolactonization were applied to connect the fragments. 2018-05-15 15:33:59 tran sequence side chain macrolactonization glycosylation sulfone convergent approach tetrahydrofuran acetyloxazolidinethione Liebeskind synthesis assembly fragment Total Synthesis condensation diastereoselective C Marine Macrolide Amphidinolide F amphidinolide F Stille cross-coupling titanium enolate