10.1021/acs.jpcc.8b01022.s001
Yun Li
Yun
Li
Wenhao Qian
Wenhao
Qian
Jin Huang
Jin
Huang
Xianjing Zhou
Xianjing
Zhou
Biao Zuo
Biao
Zuo
Xinping Wang
Xinping
Wang
Wei Zhang
Wei
Zhang
Critical Domain Sizes of Heterogeneous Nanopattern
Surfaces with Optimal Protein Resistance
American Chemical Society
2018
PMMA
Optimal Protein Resistance
surface
PEG
PS
PFMA
Heterogeneous Nanopattern Surfaces
V-shaped polymer brushes
protein molecules
Critical Domain Sizes
protein adsorption
2018-04-17 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Critical_Domain_Sizes_of_Heterogeneous_Nanopattern_Surfaces_with_Optimal_Protein_Resistance/6205130
To
investigate protein-resistant surfaces with heterogeneous nanopatterns,
V-shaped polymer brushes composed of a hydrophilic methoxypoly(ethylene
glycol) (mPEG) arm and a hydrophobic polystyrene (PS) or fluorinated
poly(methyl methacrylate) (PMMA-<i>b</i>-PFMA) arm were
prepared, in which the surface structure and phase-separation behavior
were controlled by altering the relative lengths of the two arms.
The protein resistance of these amphiphilic brushes was better than
that of pure poly(ethylene glycol) (PEG) brushes, and when the domain
size of the phase-separated structures was about twice the size of
the protein molecules, the surfaces exhibited optimal protein repellence.
At the same time, the amount of protein adsorption was well related
to both the adhesion and the relative friction coefficient of the
protein on the brush surface. A heterogeneous surface with phase-separated
domains twice the size of protein molecules may be beneficial for
minimizing protein adsorption through the synergistic effect of hydrophobic
and water-soluble domains. These results provide an important way
for designing and preparing protein-resistant materials with heterogeneous
surfaces.