%0 Journal Article %A Lang, Qiwei %A Gu, Guoxian %A Cheng, Yaoti %A Yin, Qin %A Zhang, Xumu %D 2018 %T Highly Enantioselective Synthesis of Chiral γ‑Lactams by Rh-Catalyzed Asymmetric Hydrogenation %U https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Synthesis_of_Chiral_Lactams_by_Rh-Catalyzed_Asymmetric_Hydrogenation/6194978 %R 10.1021/acscatal.8b00827.s001 %2 https://acs.figshare.com/ndownloader/files/11226092 %K chiral γ- lactams %K β- alkyl substituent %K NH %K Rh-Catalyzed Asymmetric Hydrogenation %K γ- lactams %K β- aryl %K Enantioselective Synthesis %X A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α,β-unsaturated lactams bearing a β-aryl or β-alkyl substituent were smoothly hydrogenated to provide the desired γ-lactams in up to 99% yield and 99% enantiomeric excess (ee). This methodology provides a highly practical pathway to synthesize chiral γ-lactams or γ-amino acids. %I ACS Publications