%0 Journal Article %A Feng, Wang %A Yang, Hui %A Wang, Zhe %A Gou, Bo-Bo %A Chen, Jie %A Zhou, Ling %D 2018 %T Enantioselective [3 + 2] Formal Cycloaddition of 1‑Styrylnaphthols with Quinones Catalyzed by a Chiral Phosphoric Acid %U https://acs.figshare.com/articles/journal_contribution/Enantioselective_3_2_Formal_Cycloaddition_of_1_Styrylnaphthols_with_Quinones_Catalyzed_by_a_Chiral_Phosphoric_Acid/6194822 %R 10.1021/acs.orglett.8b00988.s001 %2 https://acs.figshare.com/ndownloader/files/11224463 %K enantioselectivity %K Enantioselective %K tran %K ee %K 0.5 %K Quinones Catalyzed %K organocatalytic procedure %K cycloaddition %K enantioselective %K dr %K reactivity %K phenol %K chiral phosphoric acid %K Formal %K mol %K Chiral Phosphoric %K 1- styrylnaphthols %K diarylbenzofuran %K quinone %K Styrylnaphthol %K catalyst loading %K Cycloaddition %X The first highly enantioselective [3 + 2] formal cycloaddition of 1-styrylnaphthols (or phenol) with quinones catalyzed by a chiral phosphoric acid has been reported. A class of trans-2,3-diarylbenzofurans were prepared efficiently (up to 99% yield, >20:1 dr, 99% ee). This organocatalytic procedure allows lowering of the catalyst loading to 0.5 mol % without considerable loss in reactivity and enantioselectivity. %I ACS Publications