Nickel Dual Photoredox Catalysis for the Synthesis of Aryl Amines Ryan J. Key Aaron K. Vannucci 10.1021/acs.organomet.8b00121.s001 https://acs.figshare.com/articles/journal_contribution/Nickel_Dual_Photoredox_Catalysis_for_the_Synthesis_of_Aryl_Amines/6163742 In this work, a new dual photoredox nickel catalysis system has been utilized for the synthesize of aryl amines. Previously, our group has shown that a nickel catalyst in conjunction with a photosensitizer and a sacrificial electron donor can cross-couple C–C bonds via photoredox-assisted reductive coupling. Here we have built upon that system to develop a redox-neutral cross-coupling system for the formation of C–N bonds. The catalytic system is composed of just a nickel cross-coupling catalyst, a Ru photocatalyst, and base and is capable of coupling amines with aryl halides in good to excellent yields. Furthermore, it was found that these reactions are functional under ambient conditions with catalyst loadings of 1 mol %. Spectroscopic studies provide support that this amination mechanism proceeds via a nitrogen-based radical intermediate. This N-radical mechanism offers direct synthetic access to di- and triaryl amines from nickel photocatalysis. 2018-04-19 20:29:31 ambient conditions catalyst loadings photoredox-assisted reductive aryl amines nickel photocatalysis aryl halides N-radical mechanism electron donor Photoredox Catalysis Ru photocatalyst nickel cross-coupling catalyst nickel catalyst amination mechanism proceeds photoredox nickel catalysis system redox-neutral cross-coupling system Aryl Amines triaryl amines bond