jo052506b_si_002.cif (10.55 kB)
5-Carboxy-2-azabicyclo[2.1.1]hexanes as Precursors of 5-Halo, Amino, Phenyl, and 2-Methoxycarbonylethyl Methanopyrrolidines
dataset
posted on 2006-03-03, 00:00 authored by Grant R. Krow, Qiuli Huang, Guoliang Lin, Ryan A. Centafont, Andrew M. Thomas, Deepa Gandla, Charles DeBrosse, Patrick J. CarrollNovel 5-X-substituted-2-azabicyclo[2.1.1]hexanes (X = 5-syn-Cl, -Br, -I, -Ph, -NHCOOR (R = Me, Bn,
t-Bu), -CH2CH2COOMe and X = 5-anti-Br, -I, -Ph) were synthesized from the X = 5-syn-carboxy
derivative. New 5-anti-X-2-azabicyclo[2.1.1]hexanes, X = NHCOOR (R = Me, Bn), were prepared
stereoselectively from the X = 5-anti-carboxy substrate.
