Synthesis and Evaluation of Antimicrobial and Antibiofilm Properties
of A‑Type Procyanidin Analogues against Resistant Bacteria
in Food
Alfonso Alejo-Armijo
Nicolás Glibota
María P. Frías
Joaquín Altarejos
Antonio Gálvez
Sofía Salido
Elena Ortega-Morente
10.1021/acs.jafc.8b00535.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_and_Evaluation_of_Antimicrobial_and_Antibiofilm_Properties_of_A_Type_Procyanidin_Analogues_against_Resistant_Bacteria_in_Food/5907304
Natural
A-type procyanidins have shown very interesting biological
activities, such as their proven antiadherence properties against
pathogenic bacteria. In order to find the structural features responsible
for their activities, we describe herein the design and synthesis
of six A-type procyanidin analogues and the evaluation of their antimicrobial
and antibiofilm properties against 12 resistant bacteria, both Gram
positive and Gram negative, isolated from organic foods. The natural
A-type procyanidin A-2, which had known antiadherence activity, was
also tested as a reference compound for the comparative studies. Within
the series, analogue <b>4</b>, which had a NO<sub>2</sub> group
on ring A, showed the highest antimicrobial activity (MIC of 10 μg/mL)
and was one of the best molecules at preventing biofilm formation
(up to 40% decreases at 100 μg/mL) and disrupting preformed
biofilms (up to 40% reductions at 0.1 μg/mL). Structure–activity
relationships are also analyzed.
2018-02-20 22:14:23
biofilm formation
MIC
antibiofilm properties
Resistant Bacteria
bacteria
antimicrobial activity
antiadherence activity
2 group
analogue 4
A-type procyanidin
preformed biofilms
A-type procyanidin analogues
Antibiofilm Properties
reference compound
antiadherence properties
Food Natural A-type procyanidins