Multifunctional Biomaterial Coating Based on Bio-Inspired
Polyphosphate and Lysozyme Supramolecular Nanofilm
Xinyuan Xu
Dongyue Zhang
Shangwei Gao
Toshikazu Shiba
Quan Yuan
Kai Cheng
Hong Tan
Jianshu Li
10.1021/acs.biomac.8b00002.s001
https://acs.figshare.com/articles/journal_contribution/Multifunctional_Biomaterial_Coating_Based_on_Bio-Inspired_Polyphosphate_and_Lysozyme_Supramolecular_Nanofilm/5901871
Current implant materials have widespread
clinical applications
together with some disadvantages, the majority of which are the ease
with which infections are induced and difficulty in exhibiting biocompatibility.
For the efficient improvement of their properties, the development
of interface multifunctional modification in a simple, universal,
and environmently benign approach becomes a critical challenge and
has acquired the attention of numerous scientists. In this study,
a lysozyme-polyphosphate composite coating was fabricated for titanium(Ti)-based
biomaterial to obtain a multifunctional surface. This coating was
easily formed by sequentially soaking the substrate in reduced-lysozyme
and polyphosphate solution. Such a composite coating has shown predominant
antibacterial activity against Gram-negative bacteria (<i>E.
coli</i>) and improved cell adhesion, proliferation, and differentiation,
which are much better than those of the pure substrate. This facile
modification endows the biomaterial with anti-infective and potential
bone-regenerative performance for clinical applications of biomaterial
implants.
2018-02-12 00:00:00
cell adhesion
Gram-negative bacteria
polyphosphate solution
coating
biomaterial implants
Multifunctional Biomaterial Coating
Lysozyme Supramolecular Nanofilm
application
implant materials
Bio-Inspired Polyphosphate
bone-regenerative performance
interface multifunctional modification
multifunctional surface
substrate