Multifunctional Biomaterial Coating Based on Bio-Inspired Polyphosphate and Lysozyme Supramolecular Nanofilm Xinyuan Xu Dongyue Zhang Shangwei Gao Toshikazu Shiba Quan Yuan Kai Cheng Hong Tan Jianshu Li 10.1021/acs.biomac.8b00002.s001 https://acs.figshare.com/articles/journal_contribution/Multifunctional_Biomaterial_Coating_Based_on_Bio-Inspired_Polyphosphate_and_Lysozyme_Supramolecular_Nanofilm/5901871 Current implant materials have widespread clinical applications together with some disadvantages, the majority of which are the ease with which infections are induced and difficulty in exhibiting biocompatibility. For the efficient improvement of their properties, the development of interface multifunctional modification in a simple, universal, and environmently benign approach becomes a critical challenge and has acquired the attention of numerous scientists. In this study, a lysozyme-polyphosphate composite coating was fabricated for titanium­(Ti)-based biomaterial to obtain a multifunctional surface. This coating was easily formed by sequentially soaking the substrate in reduced-lysozyme and polyphosphate solution. Such a composite coating has shown predominant antibacterial activity against Gram-negative bacteria (<i>E. coli</i>) and improved cell adhesion, proliferation, and differentiation, which are much better than those of the pure substrate. This facile modification endows the biomaterial with anti-infective and potential bone-regenerative performance for clinical applications of biomaterial implants. 2018-02-12 00:00:00 cell adhesion Gram-negative bacteria polyphosphate solution coating biomaterial implants Multifunctional Biomaterial Coating Lysozyme Supramolecular Nanofilm application implant materials Bio-Inspired Polyphosphate bone-regenerative performance interface multifunctional modification multifunctional surface substrate