Ahmed, Basil M. Mezei, Gellert Selective, Ambient-Temperature C‑4 Deuteration of Pyrazole Derivatives by D<sub>2</sub>O A simple, inexpensive, and highly efficient procedure for the selective deuteration (up to >99% D atom %) of the C-4 position of pyrazole substrates activated by NH<sub>2</sub> or OH groups at the C-3(5) position is reported. The deuteration reaction is carried out by simply dissolving the substrate in D<sub>2</sub>O or other deuterated protic solvents, either in the absence of a catalyst with heating, or under acidic catalysis at ambient temperature; the products are obtained by simple evaporation of the solvent. D 2 O;ambient temperature;evaporation;Ambient-Temperature;absence;acidic catalysis;C -4 position;Deuteration;deuteration reaction;pyrazole substrates;NH 2;Selective;Pyrazole Derivatives;heating;protic solvents;OH groups;procedure;catalyst 2018-01-09
    https://acs.figshare.com/articles/journal_contribution/Selective_Ambient-Temperature_C_4_Deuteration_of_Pyrazole_Derivatives_by_D_sub_2_sub_O/5811018
10.1021/acs.joc.7b03062.s001