10.1021/acs.orglett.7b03828.s001
Osama El-Sepelgy
Osama
El-Sepelgy
Aleksandra Brzozowska
Aleksandra
Brzozowska
Jan Sklyaruk
Jan
Sklyaruk
Yoon Kyung Jang
Yoon Kyung
Jang
Viktoriia Zubar
Viktoriia
Zubar
Magnus Rueping
Magnus
Rueping
Cooperative Metal–Ligand Catalyzed Intramolecular
Hydroamination and Hydroalkoxylation of Allenes Using a Stable Iron
Catalyst
American Chemical Society
2018
reaction conditions
Allene
hydroalkoxylation
Hydroamination
dihydropyrrole
iron-catalyzed chemoselective intramolecular hydroamination
moisture
allene
absence
activation
Stable Iron Catalyst
5- membered heterocycles
Effective selectivity control
hydrofunctionalization
additive
Catalyzed
α- allenic amines
substrate
dihydrofuran
yield
Hydroalkoxylation
iron catalyst
Intramolecular
Cooperative
2018-01-18 19:18:39
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Cooperative_Metal_Ligand_Catalyzed_Intramolecular_Hydroamination_and_Hydroalkoxylation_of_Allenes_Using_a_Stable_Iron_Catalyst/5801256
A new iron-catalyzed
chemoselective intramolecular hydroamination
and hydroalkoxylation of the readily available α-allenic amines
and alcohols to valuable unsaturated 5-membered heterocycles, 2,3-dihydropyrrole
and 2,3-dihydrofuran, is reported. Effective selectivity control is
achieved by a metal–ligand cooperative activation of the substrates.
The mild reaction conditions and the use of low amounts of an air
and moisture stable iron catalyst allow for the hydrofunctionalization
of a wide range of allenes bearing different functional groups in
good yields in the absence of base or any sensitive additives.