10.1021/acs.orglett.7b03828.s001 Osama El-Sepelgy Osama El-Sepelgy Aleksandra Brzozowska Aleksandra Brzozowska Jan Sklyaruk Jan Sklyaruk Yoon Kyung Jang Yoon Kyung Jang Viktoriia Zubar Viktoriia Zubar Magnus Rueping Magnus Rueping Cooperative Metal–Ligand Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Allenes Using a Stable Iron Catalyst American Chemical Society 2018 reaction conditions Allene hydroalkoxylation Hydroamination dihydropyrrole iron-catalyzed chemoselective intramolecular hydroamination moisture allene absence activation Stable Iron Catalyst 5- membered heterocycles Effective selectivity control hydrofunctionalization additive Catalyzed α- allenic amines substrate dihydrofuran yield Hydroalkoxylation iron catalyst Intramolecular Cooperative 2018-01-18 19:18:39 Journal contribution https://acs.figshare.com/articles/journal_contribution/Cooperative_Metal_Ligand_Catalyzed_Intramolecular_Hydroamination_and_Hydroalkoxylation_of_Allenes_Using_a_Stable_Iron_Catalyst/5801256 A new iron-catalyzed chemoselective intramolecular hydroamination and hydroalkoxylation of the readily available α-allenic amines and alcohols to valuable unsaturated 5-membered heterocycles, 2,3-dihydropyrrole and 2,3-dihydrofuran, is reported. Effective selectivity control is achieved by a metal–ligand cooperative activation of the substrates. The mild reaction conditions and the use of low amounts of an air and moisture stable iron catalyst allow for the hydrofunctionalization of a wide range of allenes bearing different functional groups in good yields in the absence of base or any sensitive additives.